FIRE! It is with extreme regret we have to announce that Saint John has again been visited by a destructive fire, which has laid in waste eight fine stores on the east side of Prince William Street with several buildings in the rear. (see original) for names of stores, proprietors etc. But we have yet to give the most melancholy details of the catastrophy attending this awful visitation - the death of four individuals: Matthew HOLDSWORTH of the firm Holdsworth & Daniel who occupy the stone store of John WALKER immediately opposite the scene of the conflagaration and which is connected with Mr. Walker's brick store fronting on Water Street, in proceeding to examine the scuttle on the roof, accidently stepped into the hatchway in the third story of Mr. Walker's store, and fell to the ground through te other hatchways, a distance of about 30 feet, by which he was so severely bruised, that he survived the fall only a few minutes. Mr. HOLDSWORTH was age 30 and left a wife and two children. The other cases of life occurred in the rear of Mr. Donnelly's, which appears to have been occupied by six families: the wife of Mr. CAVILAND, a journeyman tailor, and two children, one of them age 2 and the other age 5, being unable to escape, perished in the flames; the other inmates escaped with difficulty, some of them with only their night clothes on.